Hypercholesterolemia impairs exercise capacity in mice
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چکیده
منابع مشابه
Hypercholesterolemia impairs immunity to tuberculosis.
We demonstrate that apolipoprotein E -deficient (ApoE(-/-)) mice are highly susceptible to tuberculosis and that their susceptibility depends on the severity of hypercholesterolemia. Wild-type (WT) mice and ApoE(-/-) mice fed a low-cholesterol (LC) or high-cholesterol (HC) diet were infected with approximately 50 CFU Mycobacterium tuberculosis Erdman by aerosol. ApoE(-/-) LC mice were modestly ...
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Insulin resistance or diabetes is associated with limited exercise capacity, which can be caused by the abnormal energy metabolism in skeletal muscle. Oxidative stress is involved in mitochondrial dysfunction in diabetes. We hypothesized that increased oxidative stress could cause mitochondrial dysfunction in skeletal muscle and make contribution to exercise intolerance in diabetes. C57/BL6J mi...
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BACKGROUND AND PURPOSE The effects of Western-type fat diet on endothelium-dependent relaxations and vascular structure in carotid arteries from a mouse model of human atherosclerosis are not known. Our objective was to characterize the mechanisms underlying endothelial dysfunction in apoE-deficient mice. METHODS C57BL/6J and apoE-deficient mice were fed for 26 weeks with a lipid-rich Western...
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ژورنال
عنوان ژورنال: Vascular Medicine
سال: 2009
ISSN: 1358-863X,1477-0377
DOI: 10.1177/1358863x08100040